CIRS & Genetic Susceptibility: Why Some People React to Biotoxins More Than Others

Why Do Some People Get Sick from Biotoxins While Others Don’t?

Not everyone who is exposed to mold, Lyme disease, or environmental toxins develops Chronic Inflammatory Response Syndrome (CIRS). Some people can clear biotoxins efficiently, while others become chronically ill due to genetic susceptibility.

This difference is largely due to variations in the human leukocyte antigen (HLA) genes, which play a crucial role in immune system function. Understanding your genetic predisposition to CIRS can help guide effective treatment strategies.

Step 1: Understanding the Role of HLA Genes in CIRS

HLA genes help the immune system recognize and remove harmful substances, including biotoxins. In up to 25% of the population, specific HLA gene variations impair the body’s ability to clear mold toxins, Lyme toxins, and other biotoxins, leading to chronic immune activation and inflammation.

How HLA Susceptibility Contributes to CIRS:

✔ Impaired Biotoxin Clearance – The body cannot properly recognize and remove toxins.
✔ Chronic Inflammation – Persistent immune activation leads to widespread symptoms.
✔ Higher Risk of Mold & Lyme-Related Illness – Increased sensitivity to water-damaged buildings and tick-borne infections.
✔ Increased Autoimmune Reactivity – The immune system may attack the body’s own tissues.
✔ Difficulty Recovering Without Targeted Treatment – Detox pathways may need additional support.

👉 Genetic Testing for HLA Susceptibility can provide insight into whether biotoxin illness is more likely to affect you.

Step 2: How to Test for Genetic Susceptibility to CIRS

If you suspect genetic susceptibility to CIRS, HLA-DR/DQ testing can help determine your risk.

Where to Get HLA-DR Testing:

✔ LabCorp or Quest Diagnostics – Standard labs that offer HLA-DR genetic testing.
✔ Functional Medicine Practitioners – Many order genetic tests as part of a broader evaluation.
✔ Self-Ordered DNA Testing Services – Some companies provide HLA-type reports.

Once tested, results will indicate whether you have a susceptible HLA type that affects your ability to detoxify biotoxins effectively.

Step 3: Supporting Detox Pathways for Genetically Susceptible Individuals

If you have an HLA genetic susceptibility, you may need additional support for detoxification to effectively clear biotoxins from your system.

Best Detox Strategies for HLA-Susceptible Individuals:

✔ Cholestyramine (CSM) & Welchol – Prescription binders that help remove mold toxins from the body.
✔ Activated Charcoal, Bentonite Clay & Chlorella – Natural binders to trap biotoxins.
✔ Glutathione & NAC – Support cellular detox and immune balance.
✔ Infrared Sauna & Sweating – Helps remove toxins through the skin.
✔ Adequate Hydration & Electrolytes – Flushes toxins more efficiently.

Step 4: Addressing Inflammation & Immune Dysfunction in Susceptible Individuals

For those with HLA susceptibility, ongoing inflammation is a major driver of CIRS symptoms.

How to Reduce Inflammation & Balance the Immune System:

✔ Omega-3 Fatty Acids & Curcumin – Reduce cytokine overactivity.
✔ Low-Histamine, Anti-Inflammatory Diet – Eliminates foods that fuel inflammation.
✔ Mast Cell Stabilizers (Quercetin, Vitamin C, DAO Enzymes) – Helps prevent excessive immune reactions.
✔ Vagus Nerve Stimulation (Deep Breathing, Meditation) – Calms the overactive immune response.
✔ Low-Dose Naltrexone (LDN) – Modulates immune function and inflammation.

Step 5: Individualized Treatment Plans for CIRS Recovery

Since genetically susceptible individuals struggle to clear toxins, a personalized approach to treatment is crucial.

Best Approaches for Genetically Susceptible CIRS Patients:

✔ Environmental Remediation – Ensure home and workspaces are free from mold and biotoxins.
✔ Comprehensive Detox Support – Use targeted binders, antioxidants, and liver support.
✔ Immune Regulation – Balance inflammation with diet, lifestyle, and medical therapies.
✔ Regular Testing & Monitoring – Track progress with labs and symptom assessment.
✔ Nervous System Regulation (DNRS, Gupta, Primal Trust) – Helps retrain immune hyperreactivity.

Final Thoughts: Genetics Are Not Destiny

While HLA susceptibility can increase the risk of developing CIRS, it does not mean recovery is impossible. With the right environmental changes, detox support, and immune regulation strategies, those with genetic susceptibility can heal and thrive.

Understanding our genetic predisposition allows for a more precise and effective treatment approach, helping us overcome chronic inflammation and regain our health.